Article
The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients.
Journal of the American College of Cardiology - 19 Mar 2003
Rossi Gian Paolo, Taddei Stefano, Virdis Agostino, Cavallin Martina, Ghiadoni Lorenzo, Favilla Stefania, Versari Daniele, Sudano Isabella, Pessina Achille C, Salvetti Antonio
Abstract excerpt
OBJECTIVES: We sought to investigate whether two polymorphisms located in the promoter (T(-786)C) and exon 7 (Glu298Asp) of the endothelial nitric oxide (NO) synthase (eNOS) gene affected agonists-mediated NO release. BACKGROUND: Endothelial dysfunction can be genetically determined. Therefore, we investigated whether two polymorphisms located in the eNOS gene affected agonists-mediated NO release. METHODS: We...
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