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Article

Adenovirus-mediated antisense ATM gene transfer sensitizes prostate cancer cells to radiation.

Cancer gene therapy - 1 Oct 2000

Fan Z, Chakravarty P, Alfieri A, Pandita T K, Vikram B, Guha C

Abstract excerpt

Treatment failure after radiation therapy of prostate cancer (PC) could be a significant problem. Our objective is to design genetic radiosensitizing strategies for the treatment of PC. Cells from individuals with the genetic disorder ataxia telangiectasia (AT) are hypersensitive to ionizing radiation. Therefore, we examined whether attenuation of the AT gene product, AT mutated (ATM), in PC cells could result in...

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Source

Identifiers

PMID: 11059687
DOI: 10.1038/sj.cgt.7700242

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Adenovirus-mediated antisense ATM gene transfer sensitizes prostate cancer cells to radiation.PMID 11059687Read ↗

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Low-dose irradiation inhibits proliferation of the p53null type human prostate cancer cells through the ATM/p21 pathway.Semantic proximity Read ↗

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