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Article

RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells.

Cancer research - 1 Apr 2005

Mukhopadhyay Utpal K, Senderowicz Adrian M, Ferbeyre Gerardo

Abstract excerpt

p53 is frequently mutated in patients with prostate cancer, especially in those with advanced disease. Therefore, the selective elimination of p53 mutant cells will likely have an impact in the treatment of prostate cancer. Because p53 has important roles in cell cycle checkpoints, it has been anticipated that modulation of checkpoint pathways should sensitize p53-defective cells to chemotherapy while sparing...

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Identifiers

PMID: 15805289
DOI: 10.1158/0008-5472.CAN-04-2502

Genes

ATM
UCN
ATR
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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