Article
A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy.
The cancer journal from Scientific American - 1 Jan 2000
Hall E J, Schiff P B, Hanks G E, Brenner D J, Russo J, Chen J, Sawant S G, Pandita T K
Abstract excerpt
PURPOSE: To investigate whether a significant proportion of prostate cancer patients who have late sequelae after high-dose external-beam conformal radiation therapy are radio-sensitive because they are carriers of ataxia-telangiectasia, that is, are heterozygous for mutations in the ATM gene. PATIENTS AND METHODS: A group of prostate cancer patients were selected who experienced severe late sequelae,...
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