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Article

A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy.

The cancer journal from Scientific American - 1 Jan 2000

Hall E J, Schiff P B, Hanks G E, Brenner D J, Russo J, Chen J, Sawant S G, Pandita T K

Abstract excerpt

PURPOSE: To investigate whether a significant proportion of prostate cancer patients who have late sequelae after high-dose external-beam conformal radiation therapy are radio-sensitive because they are carriers of ataxia-telangiectasia, that is, are heterozygous for mutations in the ATM gene. PA...

Topics

Ataxia Telangiectasia
DNA Primers
Exons
Genetic Carrier Screening
Humans
Male
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Prostatic Neoplasms
Radiation Injuries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radiation Tolerance

Source

Identifiers

PMID: 9853138

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9853138-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy.PMID 9853138Read ↗

Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.Semantic proximity Read ↗

Enhanced radiation late effects and cellular radiation sensitivity in an ATM heterozygous breast cancer patient.Semantic proximity Read ↗

<i>Atm</i> heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterpartsSemantic proximity Read ↗

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Chromosomal radiosensitivity, cancer predisposition and response to radiotherapy.Semantic proximity Read ↗

ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects.Semantic proximity Read ↗

Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous ATM mutation.Semantic proximity Read ↗

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[Adjuvant irradiation in breast cancer patients with ATM gene heterozygous mutations: special focus on clinical efficacy/toxicity].Semantic proximity Read ↗

Adenovirus-mediated antisense ATM gene transfer sensitizes prostate cancer cells to radiation.Semantic proximity Read ↗

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