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Article

Human fibroblasts transfected with an ATM antisense vector respond abnormally to ionizing radiation.

International journal of molecular medicine - 1 Jul 1999

Uhrhammer N, Fritz E, Boyden L, Meyn M S

Abstract excerpt

ATM, the gene mutated in ataxia-telangiectasia (A-T), mediates multiple cellular responses to DNA damage. A-T homozygotes have a high risk of cancer and exhibit spontaneous chromosomal instability, and cultured A-T cells react abnormally to ionizing radiation. We have developed an ATM antisense vector that confers an A-T phenotype on normal cells. An episomal antisense vector was created that contained a 1.3 kb...

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Share to Ataxia Telangiectasia
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10373636
DOI: 10.3892/ijmm.4.1.43

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Human fibroblasts transfected with an ATM antisense vector respond abnormally to ionizing radiation.PMID 10373636Read ↗

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