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Article

Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer Irradiation

28 Jul 2017

Abstract excerpt

Abstract In prostate cancer, androgen deprivation therapy (ADT) enhances the cytotoxic effects of radiotherapy. This effect is associated with weakening of the DNA damage response (DDR) normally supported by the androgen receptor. As a significant number of patients will fail combined ADT and radiotherapy, we hypothesized that DDR may be driven by androgen receptor splice variants (ARV) induced by ADT....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28754673
DOI: 10.1158/0008-5472.can-17-0164

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