Article
Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.
American journal of human genetics - 1 Feb 1995
Jongmans W, Verhaegh G W, Jaspers N G, Oshimura M, Stanbridge E J, Lohman P H, Zdzienicka M Z
Abstract excerpt
Cells derived from patients with the cancer-prone inherited disorder ataxia-telangiectasia (A-T) show an abnormal response to ionizing radiation-induced DNA damage, such as an increased cell killing and a diminished inhibition of DNA synthesis. The enhanced killing of A-T (group D) cells by X-ray...
Topics
- Animals
- Ataxia Telangiectasia
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 6
- DNA
- Dose-Response Relationship, Radiation
- Genetic Complementation Test
- Humans
- Hybrid Cells
- Mice
- Phenotype
- Radiation Tolerance
- X-Rays