Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.

American journal of human genetics - 1 Feb 1995

Jongmans W, Verhaegh G W, Jaspers N G, Oshimura M, Stanbridge E J, Lohman P H, Zdzienicka M Z

Abstract excerpt

Cells derived from patients with the cancer-prone inherited disorder ataxia-telangiectasia (A-T) show an abnormal response to ionizing radiation-induced DNA damage, such as an increased cell killing and a diminished inhibition of DNA synthesis. The enhanced killing of A-T (group D) cells by X-rays can be corrected by multiple cDNAs, mapping to different chromosomes (6, 11, 17, and 18). In order to examine whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Genetic Complementation Test

Share to Hybrid Cells

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 7847380
PMCID: PMC1801140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.PMID 7847380Read ↗

Ataxia-telangiectasia: closer to unraveling the mystery.Semantic proximity Read ↗

Functional complementation of ataxia-telangiectasia group D (AT-D) cells by microcell-mediated chromosome transfer and mapping of the AT-D locus to the region 11q22-23.Semantic proximity Read ↗

Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts.Semantic proximity Read ↗

Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants.Semantic proximity Read ↗

Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells.Semantic proximity Read ↗

Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein.Semantic proximity Read ↗

Genetic complementation analysis of ataxia telangiectasia and Nijmegen breakage syndrome: a survey of 50 patientsSemantic proximity Read ↗

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.Semantic proximity Read ↗

Functional complementation of a genetic deficiency with human artificial chromosomes.Semantic proximity Read ↗

Genetic complementation of radiation response by 3' untranslated regions (UTR) of RNA.Semantic proximity Read ↗

Mammalian X ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation.Semantic proximity Read ↗

TEL1 from Saccharomyces cerevisiae suppresses chromosome aberrations induced by ionizing radiation in ataxia-telangiectasia cells without affecting cell cycle checkpoints.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.