Article
Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Zhang N, Chen P, Khanna K K, Scott S, Gatei M, Kozlov S, Watters D, Spring K, Yen T, Lavin M F
Abstract excerpt
A gene mutated in the human genetic disorder ataxia-telangiectasia (A-T), ATM, was recently identified by positional cloning. ATM is a member of the phosphatidylinositol-3-kinase superfamily, some of which are protein kinases and appear to have important roles in cell cycle control and radiation signal transduction. We describe herein, to our knowledge, for the first time, the cloning of a full-length cDNA for...
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