Article
Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Zhang N, Chen P, Khanna K K, Scott S, Gatei M, Kozlov S, Watters D, Spring K, Yen T, Lavin M F
Abstract excerpt
A gene mutated in the human genetic disorder ataxia-telangiectasia (A-T), ATM, was recently identified by positional cloning. ATM is a member of the phosphatidylinositol-3-kinase superfamily, some of which are protein kinases and appear to have important roles in cell cycle control and radiation...
Topics
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Cell Line
- Cloning, Molecular
- DNA, Complementary
- DNA-Binding Proteins
- Herpesvirus 4, Human
- Humans
- Open Reading Frames
- Phenotype
- Protein Serine-Threonine Kinases
- Proteins