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Article

Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.

The Journal of biological chemistry - 23 Mar 2001

Gueven N, Keating K E, Chen P, Fukao T, Khanna K K, Watters D, Rodemann P H, Lavin M F

Abstract excerpt

Epidermal growth factor (EGF) has been reported to either sensitize or protect cells against ionizing radiation. We report here that EGF increases radiosensitivity in both human fibroblasts and lymphoblasts and down-regulates both ATM (mutated in ataxia-telangiectasia (A-T)) and the catalytic sub...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 11080496
DOI: 10.1074/jbc.M006190200

Genes

ATM
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11080496-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.PMID 11080496Read ↗

Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein.Semantic proximity Read ↗

ATM-Dependent and -Independent Gene Expression Changes in Response to Oxidative Stress, Gamma Irradiation, and UV IrradiationSemantic proximity Read ↗

A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to RadiosensitivitySemantic proximity Read ↗

Deficiency in the Catalytic Subunit of DNA-Dependent Protein Kinase Causes Down-Regulation of ATMSemantic proximity Read ↗

Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regenerationSemantic proximity Read ↗

Inhibition of ATM kinase activity does not phenocopy ATM protein disruptionSemantic proximity Read ↗

The Ataxia telangiectasia Gene Product Is Required for Oxidative Stress-induced G1 and G2Checkpoint Function in Human FibroblastsSemantic proximity Read ↗

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.Semantic proximity Read ↗

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.Semantic proximity Read ↗

Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.Semantic proximity Read ↗

ATM-NF-&#954;B Connection as a Target for Tumor RadiosensitizationSemantic proximity Read ↗

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.Semantic proximity Read ↗

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