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Article

Low-dose irradiation inhibits proliferation of the p53null type human prostate cancer cells through the ATM/p21 pathway.

International journal of molecular medicine - 1 Jan 2018

Li Si-Jie, Liang Xin-Yue, Li Hai-Jun, Yang Guo-Zi, Li Wei, Li Zhuo, Zhou Lei, Wen Xue, Yu De-Hai, Cui Jiu-Wei

Abstract excerpt

Low-dose ionizing radiation (LDIR) induces hormesis, exerts an adoptive effect on normal mammalian cells and stimulates cell proliferation; however, this effect is absent in cancer cells. Little is known on the molecular mechanisms underlying this differential response between normal and cancer cells. In the present study, it was demonstrated that the human prostate cancer cell line PC-3 and the normal prostate...

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Share to Ataxia Telangiectasia Mutated Proteins
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 29115439
DOI: 10.3892/ijmm.2017.3237

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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