Article
An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells.
Oncogene - 20 Aug 1998
Zhang N, Chen P, Gatei M, Scott S, Khanna K K, Lavin M F
Abstract excerpt
The cloning of a full-length cDNA for the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) has been described recently. This cDNA, as well as a fragment representing a functional region from ATM, are capable of rescuing various aspects of the radiosensitive phenotype i...
Topics
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cadmium Chloride
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle
- Cell Cycle Proteins
- Cell Division
- Cell Line
- Cell Survival
- Chromosome Aberrations
- Cloning, Molecular
- DNA
- DNA, Antisense
- DNA-Binding Proteins
- Gamma Rays
- Humans
- JNK Mitogen-Activated Protein Kinases
- Lymphocytes