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Article

An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells.

Oncogene - 20 Aug 1998

Zhang N, Chen P, Gatei M, Scott S, Khanna K K, Lavin M F

Abstract excerpt

The cloning of a full-length cDNA for the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) has been described recently. This cDNA, as well as a fragment representing a functional region from ATM, are capable of rescuing various aspects of the radiosensitive phenotype in A-T cells. We have subcloned full-length ATM cDNA in the opposite orientation in an EBV-based vector under the...

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Source

Identifiers

PMID: 9779997
DOI: 10.1038/sj.onc.1202007

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells.PMID 9779997Read ↗

Human fibroblasts transfected with an ATM antisense vector respond abnormally to ionizing radiation.Semantic proximity Read ↗

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.Semantic proximity Read ↗

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.Semantic proximity Read ↗

Recombinant ATM protein complements the cellular A-T phenotype.Semantic proximity Read ↗

Inhibition of ATM kinase activity does not phenocopy ATM protein disruptionSemantic proximity Read ↗

ATM-Dependent and -Independent Gene Expression Changes in Response to Oxidative Stress, Gamma Irradiation, and UV IrradiationSemantic proximity Read ↗

A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to RadiosensitivitySemantic proximity Read ↗

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.Semantic proximity Read ↗

Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein.Semantic proximity Read ↗

Adenovirus-mediated antisense ATM gene transfer sensitizes prostate cancer cells to radiation.Semantic proximity Read ↗

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damageSemantic proximity Read ↗

Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress.Semantic proximity Read ↗

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