Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity

15 Jan 2004

Abstract excerpt

The ATM protein, which is mutated in individuals with ataxia telangiectasia (AT), is central to cell cycle checkpoint responses initiated by DNA double-strand breaks (DSBs). ATM's role in DSB repair is currently unclear as is the basis underlying the radiosensitivity of AT cells. We applied immunofluorescence detection of gamma-H2AX nuclear foci and pulsed-field gel electrophoresis to quantify the repair of DSBs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms
Share to Radiation Therapy and Dosimetry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14744762
DOI: 10.1158/0008-5472.can-03-2384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to RadiosensitivityPMID 14744762Read ↗

Telomere Shortening Alters the Kinetics of the DNA Damage Response after Ionizing Radiation in Human CellsSemantic proximity Read ↗

ATM-Dependent and -Independent Gene Expression Changes in Response to Oxidative Stress, Gamma Irradiation, and UV IrradiationSemantic proximity Read ↗

Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related.Semantic proximity Read ↗

Inhibition of ATM kinase activity does not phenocopy ATM protein disruptionSemantic proximity Read ↗

An Overactivated ATR/CHK1 Pathway Is Responsible for the Prolonged G2 Accumulation in Irradiated AT CellsSemantic proximity Read ↗

ATM&A Key Determinant of Multiple Cellular Responses to IrradiationSemantic proximity Read ↗

Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation.Semantic proximity Read ↗

Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.Semantic proximity Read ↗

DNA Damage Responses: Mechanisms and Roles in Human DiseaseSemantic proximity Read ↗

The role of ATM in DNA damage responses and cancer.Semantic proximity Read ↗

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.Semantic proximity Read ↗

Transient ATM Kinase Inhibition Disrupts DNA Damage–Induced Sister Chromatid ExchangeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.