Article
The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive.
European journal of endocrinology - 1 Oct 2000
Martelli M L, Miano M G, Battaglia C, Trapasso F, Stella A, Iuliano R, Visconti R, Fagin J A, Santoro M, Fusco A
Abstract excerpt
OBJECTIVE: The aim of our studies was to determine whether the phenotype of the anaplastic thyroid carcinomas is dominant or recessive. In fact, it is hypothesized, on the basis of epidemiological and pathological data, that undifferentiated thyroid carcinomas are derived from differentiated tumours through a mechanism of tumour progression. DESIGN: Cell hybrids have been generated by cell fusion of anaplastic...
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