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Article

Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer.

Cancer letters - 18 Oct 2008

Hassan Nur Mohammad Monsur, Tada Mitsuhiro, Hamada Jun-ichi, Kashiwazaki Haruhiko, Kameyama Takeshi, Akhter Rahena, Yamazaki Yutaka, Yano Masahiro, Inoue Nobuo, Moriuchi Tetsuya

Abstract excerpt

Genetic alteration of p53 is a significant determining factor in the carcinogenesis. The loss of function, mutant p53 can possess a dominant negative effect on wild-type p53 and may also exert gain-of-function activity. It is, however, not clear how p53 functional status due to various types of mutation results in outcome of patients with oral cancer. A total of 60 oral SCC samples were subjected to yeast...

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Identifiers

PMID: 18555592
DOI: 10.1016/j.canlet.2008.04.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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