Article
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer research - 1 Sept 2007
van Staveren Wilma C G, Solís David Weiss, Delys Laurent, Duprez Laurence, Andry Guy, Franc Brigitte, Thomas Gerry, Libert Frédérick, Dumont Jacques E, Detours Vincent, Maenhaut Carine
Abstract excerpt
Cell lines are crucial to elucidate mechanisms of tumorigenesis and serve as tools for cancer treatment screenings. Therefore, careful validation of whether these models have conserved properties of in vivo tumors is highly important. Thyrocyte-derived tumors are very interesting for cancer biology studies because from one cell type, at least five histologically characterized different benign and malignant tumor...
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