Origin and Progression of Thyroid Epithelial Tumours: Cellular and Molecular Mechanisms

Abstract excerpt

Tumours of the thyroid follicular cell are proving to be one of the most informative models for "dissecting' the molecular genetics of multi-stage human tumorigenesis. Early thyroid tumour development is closely correlated with mutation of five alternative genes, ras, ret, trk, gsp and the TSH receptor, associated with different tumour phenotypes, providing an excellent example of genotype/phenotype correlation....

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