Article
Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression.
Molecular carcinogenesis - 1 Jan 1992
Burns J S, Blaydes J P, Wright P A, Lemoine L, Bond J A, Williams E D, Wynford-Thomas D
Abstract excerpt
Activating mutations of the ras oncogene family occur at high frequency in all stages of thyroid tumorigenesis, both human and experimental. To test the causal nature of this association, and to investigate the biological role of ras mutation, we introduced a mutant c-Ha-ras gene into normal rat thyroid follicular cells using an ecotropic retroviral vector. The major immediate effect was to greatly extend the...
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