Article
A mutated p53 gene alters thyroid cell differentiation.
Oncogene - 16 Nov 1995
Battista S, Martelli M L, Fedele M, Chiappetta G, Trapasso F, De Vita G, Battaglia C, Santoro M, Viglietto G, Fagin J A
Abstract excerpt
p53 is the gene most frequently found mutated in human neoplasias. In the majority of tumors, p53 mutations contribute to the progression towards stages of increasing malignancy with the appearance of an undifferentiated phenotype. Also in thyroid cancerogenesis, p53 mutations correlate with the loss of the differentiated phenotype. The results presented here, suggest a direct involvement of p53 in the molecular...
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