Article
A mutated p53 gene alters thyroid cell differentiation.
Oncogene - 16 Nov 1995
Battista S, Martelli M L, Fedele M, Chiappetta G, Trapasso F, De Vita G, Battaglia C, Santoro M, Viglietto G, Fagin J A
Abstract excerpt
p53 is the gene most frequently found mutated in human neoplasias. In the majority of tumors, p53 mutations contribute to the progression towards stages of increasing malignancy with the appearance of an undifferentiated phenotype. Also in thyroid cancerogenesis, p53 mutations correlate with the...
Topics
- Amino Acid Sequence
- Animals
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Down-Regulation
- Gene Expression
- Genes, p53
- Humans
- Iodide Peroxidase
- Mice
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- PAX8 Transcription Factor
- Paired Box Transcription Factors