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Article

Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53.

British journal of cancer - 1 Mar 1999

Wyllie F S, Haughton M F, Rowson J M, Wynford-Thomas D

Abstract excerpt

Differentiated thyroid carcinomas (in contrast to the rarer anaplastic form) are unusual among human cancers in displaying a remarkably low frequency of p53 mutation and appear to retain wild-type (wt) p53 function as assessed by the response of derived cell lines to DNA damage. Using one such cell line, K1, we have tested the effect of experimental abrogation of p53 function by generating matched sub-clones...

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Identifiers

PMID: 10098744
DOI: 10.1038/sj.bjc.6690177
PMCID: PMC2362227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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