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Article

p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells.

Oncogene - 13 Feb 1997

Moretti F, Farsetti A, Soddu S, Misiti S, Crescenzi M, Filetti S, Andreoli M, Sacchi A, Pontecorvi A

Abstract excerpt

Alterations of the tumor suppressor gene p53 are uncommon in differentiated thyroid neoplasia but are detected at high frequency in anaplastic thyroid carcinoma suggesting that impaired p53 function may contribute to the undifferentiated and highly aggressive phenotype of these tumors. Effects of wild type p53 (wt-p53) re-expression were investigated in a human anaplastic thyroid carcinoma cell line (ARO)...

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PMID: 9038381
DOI: 10.1038/sj.onc.1200887

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