Article
p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells.
Oncogene - 13 Feb 1997
Moretti F, Farsetti A, Soddu S, Misiti S, Crescenzi M, Filetti S, Andreoli M, Sacchi A, Pontecorvi A
Abstract excerpt
Alterations of the tumor suppressor gene p53 are uncommon in differentiated thyroid neoplasia but are detected at high frequency in anaplastic thyroid carcinoma suggesting that impaired p53 function may contribute to the undifferentiated and highly aggressive phenotype of these tumors. Effects of...
Topics
- Carcinoma
- Cell Differentiation
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Gene Expression
- Genes, p53
- Humans
- Mutation
- Phenotype
- Temperature
- Thyroid Neoplasms
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53