p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas.

doi:10.1111/j.1349-7006.1992.tb02761.x

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Article

p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas.

Japanese journal of cancer research : Gann - 1 Dec 1992

Nakamura T, Yana I, Kobayashi T, Shin E, Karakawa K, Fujita S, Miya A, Mori T, Nishisho I, Takai S

Abstract excerpt

Anaplastic carcinoma of the thyroid gland, which is one of the most aggressive, malignant tumors in humans, is considered to originate from preexisting differentiated thyroid cancer. To define the genetic alterations associated with such progression, we examined nine cases of anaplastic thyroid c...

Topics

Base Sequence
Carcinoma
Carcinoma, Papillary
Codon
DNA Mutational Analysis
DNA, Neoplasm
Exons
Genes, p53
Humans
Molecular Sequence Data
Mutation
Thyroid Neoplasms

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