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Article

p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas.

Japanese journal of cancer research : Gann - 1 Dec 1992

Nakamura T, Yana I, Kobayashi T, Shin E, Karakawa K, Fujita S, Miya A, Mori T, Nishisho I, Takai S

Abstract excerpt

Anaplastic carcinoma of the thyroid gland, which is one of the most aggressive, malignant tumors in humans, is considered to originate from preexisting differentiated thyroid cancer. To define the genetic alterations associated with such progression, we examined nine cases of anaplastic thyroid carcinoma for mutation in exons 4-9 of the p53 tumor suppressor gene. Preliminary screening for mutation by RNase...

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Identifiers

PMID: 1483945
DOI: 10.1111/j.1349-7006.1992.tb02761.x
PMCID: PMC5918745

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Source receipt: pubmed, retrieved 7 Sept 2026.

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