Evasion of p53-mediated growth control occurs by three alternative mechanisms in transformed thyroid epithelial cells.

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Article

Evasion of p53-mediated growth control occurs by three alternative mechanisms in transformed thyroid epithelial cells.

Oncogene - 5 Jan 1995

Wyllie F S, Haughton M F, Blaydes J P, Schlumberger M, Wynford-Thomas D

Abstract excerpt

Using the thyroid as a model of multistep epithelial tumorigenesis, we have used representative cell lines to correlate the degree of malignant transformation with the functional status of p53 and the integrity of cell-cycle check-points. Three distinct phenotypes were observed: Type I lines, derived from poorly-differentiated human thyroid cancers, expressed high levels of mutant p53 protein; Type II, also...

Topics

Animals
Bleomycin
Cell Division
Cell Transformation, Neoplastic
DNA Damage
DNA Primers
Dose-Response Relationship, Drug
Epithelium
Gene Expression Regulation, Neoplastic
Genes, p53
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Rats

Thyroid Gland

Thyroid Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7529918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7529918-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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