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Article

An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria.

Nucleic acids research - 1 Oct 2000

Coffey G, Campbell C

Abstract excerpt

Mammalian mitochondrial DNA end-binding activity is nearly indistinguishable from that of nuclear Ku. This observation led to the hypothesis that mitochondrial DNA end-binding activity is in part dependent upon Ku80 gene expression. To test this hypothesis, we assayed for Ku activity in mitochondrial extracts prepared from the xrs-5 hamster cell line that lacks Ku80 mRNA expression. Mitochondrial protein extracts...

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Identifiers

PMID: 11000272
DOI: 10.1093/nar/28.19.3793
PMCID: PMC110772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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