Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

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Article

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

The Journal of biological chemistry - 10 Jun 1994

Getts R C, Stamato T D

Abstract excerpt

Double-strand DNA break repair is important in maintaining the genetic integrity of the genome. Using a mobility shift assay, we find that a protein, or complex of proteins, that is present in mammalian and yeast cells binds to the ends of double-strand DNA and renders the ends resistant to exonuclease digestion. Additionally, a mammalian DNA double-strand repair-deficient mutant, xrs, has no observable DNA end...

Topics

Animals
Antibodies, Monoclonal
Antigens, Nuclear
Cell Nucleus
Cricetinae
DNA
DNA Helicases
DNA Repair
DNA-Binding Proteins
Exodeoxyribonucleases
Humans
Ku Autoantigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Nuclear Proteins

Protein Binding

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 8206892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8206892-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.PMID 8206892Read ↗

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Molecular and biochemical characterization of xrs mutants defective in Ku80.Semantic proximity Read ↗

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.Semantic proximity Read ↗

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Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.Semantic proximity Read ↗

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DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex.Semantic proximity Read ↗

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