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Article

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

The Journal of biological chemistry - 10 Jun 1994

Getts R C, Stamato T D

Abstract excerpt

Double-strand DNA break repair is important in maintaining the genetic integrity of the genome. Using a mobility shift assay, we find that a protein, or complex of proteins, that is present in mammalian and yeast cells binds to the ends of double-strand DNA and renders the ends resistant to exonuclease digestion. Additionally, a mammalian DNA double-strand repair-deficient mutant, xrs, has no observable DNA end...

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PMID: 8206892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 8 closest

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.PMID 8206892Read ↗

An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria.Semantic proximity Read ↗

Molecular and biochemical characterization of xrs mutants defective in Ku80.Semantic proximity Read ↗

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.Semantic proximity Read ↗

Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86.Semantic proximity Read ↗

Human Ku70/80 Protein Blocks Exonuclease 1-mediated DNA Resection in the Presence of Human Mre11 or Mre11/Rad50 Protein ComplexSemantic proximity Read ↗

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.Semantic proximity Read ↗

Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.Semantic proximity Read ↗

DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex.Semantic proximity Read ↗

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