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Article

Molecular and biochemical characterization of xrs mutants defective in Ku80.

Molecular and cellular biology - 1 Mar 1997

Singleton B K, Priestley A, Steingrimsdottir H, Gell D, Blunt T, Jackson S P, Lehmann A R, Jeggo P A

Abstract excerpt

The gene product defective in radiosensitive CHO mutants belonging to ionizing radiation complementation group 5, which includes the extensively studied xrs mutants, has recently been identified as Ku80, a subunit of the Ku protein and a component of DNA-dependent protein kinase (DNA-PK). Several group 5 mutants, including xrs-5 and -6, lack double-stranded DNA end-binding and DNA-PK activities. In this study, we...

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Identifiers

PMID: 9032253
DOI: 10.1128/MCB.17.3.1264
PMCID: PMC231851

Genes

XRCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular and biochemical characterization of xrs mutants defective in Ku80.PMID 9032253Read ↗

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