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Article

A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen.

The Journal of biological chemistry - 20 Nov 1998

Wang J, Dong X, Reeves W H

Abstract excerpt

Ku autoantigen, a heterodimer of 70- and 80-kDa subunits, is a DNA end-binding factor critical for DNA repair. Two domains of p70 mediate DNA binding, one on the C-terminal and one on the N-terminal portion. The latter must dimerize with p80 in order to bind DNA, whereas the former is p80-independent. Both must be intact for end binding activity in gel shift assays. To evaluate the role of p80 in DNA binding,...

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Identifiers

PMID: 9813006
DOI: 10.1074/jbc.273.47.31068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen.PMID 9813006Read ↗

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