Article
A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen.
The Journal of biological chemistry - 20 Nov 1998
Wang J, Dong X, Reeves W H
Abstract excerpt
Ku autoantigen, a heterodimer of 70- and 80-kDa subunits, is a DNA end-binding factor critical for DNA repair. Two domains of p70 mediate DNA binding, one on the C-terminal and one on the N-terminal portion. The latter must dimerize with p80 in order to bind DNA, whereas the former is p80-indepen...
Topics
- Antigens, Nuclear
- Autoantigens
- Binding Sites
- DNA
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Dimerization
- Epitopes
- Humans
- Ku Autoantigen
- Models, Molecular
- Mutation
- Nuclear Proteins
- Nucleic Acid Conformation
- Peptide Fragments
- Precipitin Tests
- Protein Binding