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Article

Defining functional domains of Ku80: DNA end binding and survival after radiation.

Biochemical and biophysical research communications - 11 Aug 1999

Osipovich O, Duhe R J, Hasty P, Durum S K, Muegge K

Abstract excerpt

The Ku heterodimeric protein (Ku80/Ku70) is an essential component of the double-strand break DNA repair pathway in mammalian cells. We have recently defined a central region within Ku80 that is required for heterodimerization with Ku70. We now identified a core region within Ku80 (amino acids 210 to 531) that is necessary for binding of Ku to DNA ends. Interaction with Ku70 and DNA end binding are important for...

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Source

Identifiers

PMID: 10441505
DOI: 10.1006/bbrc.1999.1118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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