Article
Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.
Mutation research - 2 Jan 1996
Chen F, Peterson S R, Story M D, Chen D J
Abstract excerpt
The Chinese hamster ovary (CHO) mutant cell line xrs-6C is highly sensitive to radiation and is deficient in DNA double-strand break (DSB) repair. The repair defect of xrs-6C is complemented by the human DSB repair gene designated as XRCC5. This gene was recently identified as Ku80, which encodes...
Topics
- Animals
- Antigens, Nuclear
- Autoantigens
- Base Sequence
- Blotting, Northern
- CHO Cells
- Cell Survival
- Cricetinae
- DNA Helicases
- DNA Mutational Analysis
- DNA Primers
- DNA Repair
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Fibroblasts
- Humans
- Ku Autoantigen
- Molecular Sequence Data