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Article

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.

Mutation research - 2 Jan 1996

Chen F, Peterson S R, Story M D, Chen D J

Abstract excerpt

The Chinese hamster ovary (CHO) mutant cell line xrs-6C is highly sensitive to radiation and is deficient in DNA double-strand break (DSB) repair. The repair defect of xrs-6C is complemented by the human DSB repair gene designated as XRCC5. This gene was recently identified as Ku80, which encodes the human autoantigen protein Ku p80. Ku80 protein forms heterodimer with the Ku70 subunit to form a complex that...

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Source

Identifiers

PMID: 8538653
DOI: 10.1016/0921-8777(95)00026-7

Genes

XRCC5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.PMID 8538653Read ↗

Molecular and biochemical characterization of xrs mutants defective in Ku80.Semantic proximity Read ↗

Molecular and biochemical characterization of new X-ray-sensitive hamster cell mutants defective in Ku80.Semantic proximity Read ↗

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Differential gene expression in a DNA double-strand-break repair mutant XRS-5 defective in Ku80: analysis by cDNA microarray.Semantic proximity Read ↗

A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells.Semantic proximity Read ↗

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ATM dysfunction in Chinese hamster XRCC8 mutants.Semantic proximity Read ↗

Molecular analysis of Ku redox regulation.Semantic proximity Read ↗

The Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm, for the nuclear translocation of Ku80, and for Ku80-dependent DNA repair.Semantic proximity Read ↗

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