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Article

Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86.

Journal of cell science - 1 Jan 2003

Matheos Diamanto, Novac Olivia, Price Gerald B, Zannis-Hadjopoulos Maria

Abstract excerpt

The radiosensitive mutant xrs-5, a derivative of the Chinese hamster ovary (CHO) K1 cell line, is defective in DNA double-strand break repair and V(D)J recombination. The defective phenotypes of xrs-5 cells are complemented by the 86 kDa subunit of Ku antigen. OBA is a protein, previously purified from HeLa cells, that binds in a sequence-specific manner to mammalian origins of DNA replication. The DNA-binding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12456721
DOI: 10.1242/jcs.00156

Genes

DHFR
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86.PMID 12456721Read ↗

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