Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86.

doi:10.1242/jcs.00156

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Article

Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86.

Journal of cell science - 1 Jan 2003

Matheos Diamanto, Novac Olivia, Price Gerald B, Zannis-Hadjopoulos Maria

Abstract excerpt

The radiosensitive mutant xrs-5, a derivative of the Chinese hamster ovary (CHO) K1 cell line, is defective in DNA double-strand break repair and V(D)J recombination. The defective phenotypes of xrs-5 cells are complemented by the 86 kDa subunit of Ku antigen. OBA is a protein, previously purified from HeLa cells, that binds in a sequence-specific manner to mammalian origins of DNA replication. The DNA-binding...

Topics

Animals
Antigens, Nuclear
CHO Cells
Cell Extracts
Cricetinae
DNA Helicases
DNA Repair
DNA Replication
DNA-Binding Proteins
Eukaryotic Cells
Gene Expression Regulation
Ku Autoantigen
Mutation
Nuclear Proteins
Plasmids
Replication Origin

Source

Open in PubMed

Identifiers

PMID: 12456721
DOI: 10.1242/jcs.00156

Genes

DHFR
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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