Article
Differential gene expression in a DNA double-strand-break repair mutant XRS-5 defective in Ku80: analysis by cDNA microarray.
Journal of radiation research - 1 Dec 2001
Chan J Y, Chen L K, Chang J F, Ting H M, Goy C, Chen J L, Hwang J J, Chen F D, Chen D J, Ngo F Q
Abstract excerpt
The ability of cells to rejoin DNA double-strand breaks (DSBs) usually correlates with their radiosensitivity. This correlation has been demonstrated in radiosensitive cells, including the Chinese hamster ovary mutant XRS-5. XRS-5 is defective in a DNA end-binding protein, Ku80, which is a component of a DNA-dependent protein kinase complex used for joining strand breaks. However, Ku80-deficient cells are known...
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