Molecular and biochemical characterization of new X-ray-sensitive hamster cell mutants defective in Ku80.

doi:10.1093/nar/26.19.4332

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Article

Molecular and biochemical characterization of new X-ray-sensitive hamster cell mutants defective in Ku80.

Nucleic acids research - 1 Oct 1998

Errami A, Finnie N J, Morolli B, Jackson S P, Lohman P H, Zdzienicka M Z

Abstract excerpt

Ku, a heterodimer of approximately 70 and approximately 80 kDa subunits, is a nuclear protein that binds to double-stranded DNA ends and is a component of the DNA-dependent protein kinase (DNA-PK). Cell lines defective in Ku80 belong to group XRCC5 of ionizing radiation-sensitive mutants. Five ne...

Topics

Animals
Antigens, Nuclear
Cell Line
Cricetinae
DNA Helicases
DNA-Binding Proteins
Ku Autoantigen
Mutation
Nuclear Proteins
Radiation Tolerance
X-Rays

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