Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants.

doi:10.1128/MCB.16.4.1519

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Article

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants.

Molecular and cellular biology - 1 Apr 1996

Errami A, Smider V, Rathmell W K, He D M, Hendrickson E A, Zdzienicka M Z, Chu G

Abstract excerpt

X-ray-sensitive hamster cells in complementation groups 4, 5, 6, and 7 are impaired for both double-strand break repair and V(D)J recombination. Here we show that in two mutant cell lines (XR-V15B and XR-V9B) from group 5, the genetic defects are in the gene encoding the 86-kDa subunit of the Ku...

Topics

Amino Acid Sequence
Animals
Antigens, Nuclear
Autoantigens
Base Sequence
Cell Survival
Cricetinae
Cricetulus
DNA Helicases
DNA Nucleotidyltransferases
DNA-Binding Proteins
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ku Autoantigen

Molecular Sequence Data

Mutation

Nuclear Proteins

Radiation Tolerance

Sequence Alignment

Source

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Identifiers

PMID: 8657125
DOI: 10.1128/MCB.16.4.1519
PMCID: PMC231136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8657125-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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