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Article

Requirements for 5'dRP/AP lyase activity in Ku.

Nucleic acids research - 1 Jan 2014

Strande Natasha T, Carvajal-Garcia Juan, Hallett Ryan A, Waters Crystal A, Roberts Steven A, Strom Christina, Kuhlman Brian, Ramsden Dale A

Abstract excerpt

The non-homologous end joining (NHEJ) pathway is used in diverse species to repair chromosome breaks, and is defined in part by a requirement for Ku. We previously demonstrated mammalian Ku has intrinsic 5' deoxyribosephosphate (5'dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed this activity is important for excising abasic site damage from ends. Here we employ systematic mutagenesis to clarify the...

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Identifiers

PMID: 25200085
DOI: 10.1093/nar/gku796
PMCID: PMC4176175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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