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Article

A novel mutational hotspot in a natural quasipalindrome in Escherichia coli.

Journal of molecular biology - 22 Sept 2000

Viswanathan M, Lacirignola J J, Hurley R L, Lovett S T

Abstract excerpt

We have found that most spontaneous mutations in the thyA gene of Escherichia coli selected for resistance to trimethoprim result from a TA to AT transversion at a single site within an imperfect inverted repeat or quasipalindrome sequence. This natural quasipalindrome within the coding region of thyA contains an extraordinarily potent hotspot for mutation. Our analysis provides evidence that these mutations are...

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Share to DNA Replication
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Repetitive Sequences, Nucleic Acid

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Source

Identifiers

PMID: 10986118
DOI: 10.1006/jmbi.2000.4088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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