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Article

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.

Nature - 16 Jan 1992

Maki H, Sekiguchi M

Abstract excerpt

Errors in the replication of DNA are a major source of spontaneous mutations, and a number of cellular functions are involved in correction of these errors to keep the frequency of spontaneous mutations very low. We report here a novel mechanism which prevents replicational errors by degrading a potent mutagenic substrate for DNA synthesis. This error-avoiding process is catalysed by a protein encoded by the mutT...

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Identifiers

PMID: 1309939
DOI: 10.1038/355273a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.PMID 1309939Read ↗

The role of the mutT gene of Escherichia coli in maintaining replication fidelitySemantic proximity Read ↗

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.Semantic proximity Read ↗

Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains.Semantic proximity Read ↗

Increased A:T-->C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: direct evidence for MutT involvement in the prevention of mutations by oxidized dGTP.Semantic proximity Read ↗

A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.Semantic proximity Read ↗

The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.Semantic proximity Read ↗

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.Semantic proximity Read ↗

Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.Semantic proximity Read ↗

A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage.Semantic proximity Read ↗

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing.Semantic proximity Read ↗

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.Semantic proximity Read ↗

Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli.Semantic proximity Read ↗

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