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Article

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.

Nature - 16 Jan 1992

Maki H, Sekiguchi M

Abstract excerpt

Errors in the replication of DNA are a major source of spontaneous mutations, and a number of cellular functions are involved in correction of these errors to keep the frequency of spontaneous mutations very low. We report here a novel mechanism which prevents replicational errors by degrading a potent mutagenic substrate for DNA synthesis. This error-avoiding process is catalysed by a protein encoded by the mutT...

Topics

Bacterial Proteins
Base Composition
Base Sequence
DNA Replication
Deoxyadenine Nucleotides
Escherichia coli
Escherichia coli Proteins
Hydrolysis
Kinetics
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoric Monoester Hydrolases

Pyrophosphatases

Substrate Specificity

Templates, Genetic

Source

Identifiers

PMID: 1309939
DOI: 10.1038/355273a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1309939-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.PMID 1309939Read ↗

The role of the mutT gene of Escherichia coli in maintaining replication fidelitySemantic proximity Read ↗

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.Semantic proximity Read ↗

Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains.Semantic proximity Read ↗

Increased A:T-->C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: direct evidence for MutT involvement in the prevention of mutations by oxidized dGTP.Semantic proximity Read ↗

A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.Semantic proximity Read ↗

The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.Semantic proximity Read ↗

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.Semantic proximity Read ↗

Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.Semantic proximity Read ↗

A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage.Semantic proximity Read ↗

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing.Semantic proximity Read ↗

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.Semantic proximity Read ↗

Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli.Semantic proximity Read ↗

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