Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Hot and Cold Regions for Mutagenesis in the Escherichia coli tdk Gene: A Catalog of Mutational Sites.

Environmental and molecular mutagenesis - 1 Aug 2025

Douglas Katherine, Sorensen Dana, Saud Arnav, Sridharan Ananya, Mathew Mallika, Hiranandani Jyotsna, Gonick Ava, Young Courtney, Nguyen Kelly, Phi Nhu, Miller Jeffrey H

Abstract excerpt

We constructed a catalog of mutational sites in the tdk gene of Escherichia coli that consists of 378 different base pair substitutions at 245 different sites (base pairs). This allows us to examine the tendency of different sub-regions of the gene to be more or less prone to mutations when compared with other sub-regions. We do this by recording the number of occurrences of close to 1100 mutations resulting from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli
Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40545606
DOI: 10.1002/em.70021
PMCID: PMC12451230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Hot and Cold Regions for Mutagenesis in the Escherichia coli tdk Gene: A Catalog of Mutational Sites.PMID 40545606Read ↗

Anatomy of a hotspot: Cisplatin hotspots in the tdk gene of Escherichia coli.Semantic proximity Read ↗

Enhanced characterization of the thyA system for mutational analysis in Escherichia coli: Defining mutationally "hot" regions of the gene.Semantic proximity Read ↗

Analysis of Mutagenesis in the Escherichia coli tdk Gene: The Nucleoid Protein HNS Is Required for a Dramatic Cisplatin-Induced Hotspot.Semantic proximity Read ↗

A novel mutational hotspot in a natural quasipalindrome in Escherichia coli.Semantic proximity Read ↗

A mutation spectra database for bacterial and mammalian genes.Semantic proximity Read ↗

Temperature responses of mutation rate and mutational spectrum in an Escherichia coli strain and the correlation with metabolic rate.Semantic proximity Read ↗

Escherichia coli thymidylate kinase: molecular cloning, nucleotide sequence, and genetic organization of the corresponding tmk locus.Semantic proximity Read ↗

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Semantic proximity Read ↗

Cis and trans-acting effects on a mutational hotspot involving a replication template switch.Semantic proximity Read ↗

Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing.Semantic proximity Read ↗

Metagenomic DNA fragments that affect Escherichia coli mutational pathways.Semantic proximity Read ↗

Mutation hot spots in yeast caused by long-range clustering of homopolymeric sequences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.