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Article

Cis and trans-acting effects on a mutational hotspot involving a replication template switch.

Journal of molecular biology - 17 Feb 2006

Dutra Bethany E, Lovett Susan T

Abstract excerpt

A natural mutational hotspot in the thyA gene of Escherichia coli accounts for over half of the mutations that inactivate this gene, which can be selected by resistance to the antibiotic trimethoprim. This T to A transversion, at base 131 of the coding sequence, occurs within a 17 bp quasi-palindromic sequence. To clarify the mechanism of mutagenesis, we examine here cis and trans-acting factors affecting thyA131...

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Identifiers

PMID: 16376936
DOI: 10.1016/j.jmb.2005.11.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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