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Article

Azidothymidine and other chain terminators are mutagenic for template-switch-generated genetic mutations.

Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012

Seier Tracey, Zilberberg Gal, Zeiger Danna M, Lovett Susan T

Abstract excerpt

The accumulation of mutations causes cell lethality and can lead to carcinogenesis. An important class of mutations, which are associated with mutational hotspots in many organisms, are those that arise by nascent strand misalignment and template-switching at the site of short repetitive sequences in DNA. Mutagens that strongly and specifically affect this class, which is mechanistically distinct from other...

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Identifiers

PMID: 22474374
DOI: 10.1073/pnas.1116160109
PMCID: PMC3341039

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