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Article

Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains.

Molecular microbiology - 1 Dec 2012

Yamada Masami, Shimizu Masatomi, Katafuchi Atsushi, Grúz Petr, Fujii Shingo, Usui Yukio, Fuchs Robert P, Nohmi Takehiko

Abstract excerpt

Reactive oxygen species induce oxidative damage in DNA precursors, i.e. dNTPs, leading to point mutations upon incorporation. Escherichia coli mutT strains, deficient in the activity hydrolysing 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP), display more than a 100-fold higher spontaneous mutation frequency over the wild-type strain. 8-oxo-dGTP induces A to C transversions when misincorporated...

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Identifiers

PMID: 23043439
DOI: 10.1111/mmi.12061
PMCID: PMC3556519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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