Article
Identifying Small Molecules That Promote Quasipalindrome-Associated Template-Switch Mutations in Escherichia coli.
G3 (Bethesda, Md.) - 4 May 2020
Klaric Julie A, Perr Eli L, Lovett Susan T
Abstract excerpt
DNA can assemble into non-B form structures that stall replication and cause genomic instability. One such secondary structure results from an inverted DNA repeat that can assemble into hairpin and cruciform structures during DNA replication. Quasipalindromes (QP), imperfect inverted repeats, are sites of mutational hotspots. Quasipalindrome-associated mutations (QPMs) occur through a template-switch mechanism in...
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