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Article

The patched gene in development and cancer.

Current opinion in genetics & development - 1 Feb 1998

Ingham P W

Abstract excerpt

The cloning of vertebrate homologues of the Drosophila segment polarity gene patched has led to confirmation of a role for the multipass transmembrane protein which it encodes as a receptor for secreted signalling proteins of the Hedgehog family. In addition, human patched has been identified as a tumour suppressor gene implicated in basal cell carcinomas and medullablastomas.

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Identifiers

PMID: 9529611
DOI: 10.1016/s0959-437x(98)80067-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The patched gene in development and cancer.PMID 9529611Read ↗

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The hedgehog pathway and basal cell carcinomas.Semantic proximity Read ↗

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The role of hedgehog signalling in tumorigenesis.Semantic proximity Read ↗

Developmental genes and cancer: role of patched in basal cell carcinoma of the skin.Semantic proximity Read ↗

The Sonic Hedgehog–Patched–Gli Pathway in Human Development and DiseaseSemantic proximity Read ↗

Mutations in the human homologue of the Drosophila segment polarity gene patched in oral squamous cell carcinoma cell lines.Semantic proximity Read ↗

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

Patched2 modulates tumorigenesis in patched1 heterozygous mice.Semantic proximity Read ↗

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