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Article

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets.

Development (Cambridge, England) - 1 Dec 1995

Johnson R L, Grenier J K, Scott M P

Abstract excerpt

The membrane protein, Patched, plays a critical role in patterning embryonic and imaginal tissues in Drosophila. patched constitutively inactivates the transcription of target genes such as wingless, decapentaplegic, and patched itself. The secreted protein, Hedgehog, induces transcription of target genes by opposing the Patched signaling pathway. Using the Gal4 UAS system we have overexpressed patched in wing...

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Identifiers

PMID: 8575316
DOI: 10.1242/dev.121.12.4161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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