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Article

The patched signaling pathway in tumorigenesis and development: lessons from animal models.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 1999

Hahn H, Wojnowski L, Miller G, Zimmer A

Abstract excerpt

The identification of mutations in the human homolog of the Drosophila segment polarity gene Patched in basal cell carcinoma has sparked intense interest in the role of this gene in human disorders. The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. Sonic Hedgehog/Patched signaling involves another transmembrane protein, Smoothened, and its intracellular effectors, including the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10475061
DOI: 10.1007/s001099900018

Genes

GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The patched signaling pathway in tumorigenesis and development: lessons from animal models.PMID 10475061Read ↗

The patched gene in development and cancer.Semantic proximity Read ↗

The hedgehog pathway and basal cell carcinomas.Semantic proximity Read ↗

Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures.Semantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.Semantic proximity Read ↗

The Hedgehog signalling pathway and cancer.Semantic proximity Read ↗

The Sonic Hedgehog–Patched–Gli Pathway in Human Development and DiseaseSemantic proximity Read ↗

The role of hedgehog signalling in tumorigenesis.Semantic proximity Read ↗

Patched2 modulates tumorigenesis in patched1 heterozygous mice.Semantic proximity Read ↗

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.Semantic proximity Read ↗

Mutations in the human homologue of the Drosophila segment polarity gene patched in oral squamous cell carcinoma cell lines.Semantic proximity Read ↗

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