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Article

The role of ciliary trafficking in Hedgehog receptor signaling

2 Jun 2015

Abstract excerpt

Defects in the biogenesis of or transport through primary cilia affect Hedgehog protein signaling, and many Hedgehog pathway components traffic through or accumulate in cilia. The Hedgehog receptor Patched negatively regulates the activity and ciliary accumulation of Smoothened, a seven-transmembrane protein that is essential for transducing the Hedgehog signal. We found that this negative regulation of...

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PMID: 26038600
DOI: 10.1126/scisignal.aaa5622

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