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Article

Characterization of two patched receptors for the vertebrate hedgehog protein family

10 Nov 1998

Abstract excerpt

The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh), a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein Smoothened (SMO) by PTCH. According to this model, the inhibition of SMO signaling is relieved after mutational...

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Identifiers

PMID: 9811851
DOI: 10.1073/pnas.95.23.13630

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Related research

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Research trail→

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Characterization of two patched receptors for the vertebrate hedgehog protein familyPMID 9811851Read ↗

Patched2 modulates tumorigenesis in patched1 heterozygous mice.Semantic proximity Read ↗

The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexesSemantic proximity Read ↗

Ptch2 mediates the Shh response in Ptch1-/- cells.Semantic proximity Read ↗

Dual roles for patched in sequestering and transducing Hedgehog.Semantic proximity Read ↗

Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling.Semantic proximity Read ↗

Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.Semantic proximity Read ↗

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.Semantic proximity Read ↗

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.Semantic proximity Read ↗

Structural basis of sterol recognition by human hedgehog receptor PTCH1Semantic proximity Read ↗

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.Semantic proximity Read ↗

Patched1 is required in neural crest cells for the prevention of orofacial clefts.Semantic proximity Read ↗

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.Semantic proximity Read ↗

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