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Article

Regulation of the oncoprotein Smoothened by small molecules.

Nature chemical biology - 1 Apr 2015

Sharpe Hayley J, Wang Weiru, Hannoush Rami N, de Sauvage Frederic J

Abstract excerpt

The Hedgehog pathway is critical for animal development and has been implicated in multiple human malignancies. Despite great interest in targeting the pathway pharmacologically, many of the principles underlying the signal transduction cascade remain poorly understood. Hedgehog ligands are recognized by a unique receptor system that features the transporter-like protein Patched and the G protein-coupled receptor...

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PMID: 25785427
DOI: 10.1038/nchembio.1776

Genes

SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Regulation of the oncoprotein Smoothened by small molecules.PMID 25785427Read ↗

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Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.Semantic proximity Read ↗

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.Semantic proximity Read ↗

Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.Semantic proximity Read ↗

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