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Article

Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model

23 Sept 2009

Abstract excerpt

Mouse models of intestinal tumors have advanced our understanding of the role of gene mutations in colorectal malignancy. However, the utility of these systems for studying the role of epigenetic alterations in intestinal neoplasms remains to be defined. Consequently, we assessed the role of aberrant DNA methylation in the azoxymethane (AOM) rodent model of colon cancer. AOM induced tumors display global DNA...

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Share to Cancer-related gene regulation
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PMID: 19777566
DOI: 10.1002/mc.20581

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