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Article

Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2011

Trbusek Martin, Smardova Jana, Malcikova Jitka, Sebejova Ludmila, Dobes Petr, Svitakova Miluse, Vranova Vladimira, Mraz Marek, Francova Hana Skuhrova, Doubek Michael, Brychtova Yvona, Kuglik Petr, Pospisilova Sarka, Mayer Jiri

Abstract excerpt

PURPOSE: There is a distinct connection between TP53 defects and poor prognosis in chronic lymphocytic leukemia (CLL). It remains unclear whether patients harboring TP53 mutations represent a homogenous prognostic group. PATIENTS AND METHODS: We evaluated the survival of patients with CLL and p53 defects identified at our institution by p53 yeast functional assay and complementary interphase fluorescence in situ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, p53

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 21606432
DOI: 10.1200/JCO.2011.34.7872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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