p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

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Article

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

Cancer research - 15 Nov 1994

Fan S, el-Deiry W S, Bae I, Freeman J, Jondle D, Bhatia K, Fornace A J, Magrath I, Kohn K W, O'Connor P M

Abstract excerpt

The present study assessed the role of the p53 tumor suppressor gene in cell cycle arrest and apoptosis following treatment of Burkitt's lymphoma and lymphoblastoid cell lines with gamma-rays, etoposide, nitrogen mustard, and cisplatin. Cell cycle arrest was measured by flow cytometry; p53 and p2...

Topics

Apoptosis
Burkitt Lymphoma
Cisplatin
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA Topoisomerases, Type II
Drug Resistance
Etoposide
Flow Cytometry
G1 Phase
Gamma Rays
Genes, p53
Humans
Lymphocytes
Mechlorethamine
Mutation
Nocodazole
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7954409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7954409-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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