Article
Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993
Gupta R K, Patel K, Bodmer W F, Bodmer J G
Abstract excerpt
The p53 tumor-suppressor gene encodes a nuclear phosphoprotein that arrests cell cycle progress at G1. It may facilitate DNA damage repair and is frequently mutated in many human tumors. Hodgkin disease, a malignant condition of the lymphoid system, is characterized by the presence of Reed-Sternb...
Topics
- Base Sequence
- Biopsy
- Blotting, Western
- Cell Nucleus
- Codon
- DNA Damage
- DNA, Neoplasm
- Genes, p53
- Hodgkin Disease
- Humans
- In Situ Hybridization
- Mitosis
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Reed-Sternberg Cells
- Tumor Cells, Cultured