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Article

Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993

Gupta R K, Patel K, Bodmer W F, Bodmer J G

Abstract excerpt

The p53 tumor-suppressor gene encodes a nuclear phosphoprotein that arrests cell cycle progress at G1. It may facilitate DNA damage repair and is frequently mutated in many human tumors. Hodgkin disease, a malignant condition of the lymphoid system, is characterized by the presence of Reed-Sternberg cells and mononuclear variants (Hodgkin cells), whose etiology remains unknown. The large multinucleated...

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Identifiers

PMID: 8464894
DOI: 10.1073/pnas.90.7.2817
PMCID: PMC46187

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